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Right on the heels of a personal tragedy, Wade Wilson (Ryan Reynolds) hits rock bottom and decides to end his life, even though he is well-aware that it is never going to happen. Rescued by his X-Men friend Colossus (Stefan Kapičić) from his slumber, he gets to spend time recuperating at the X-Mansion until a new mission comes along, which turns him into an X-Men trainee. Russell (Julian Dennison), a young pyrokinetic mutant, decides to wreak havoc at the orphanage whose staff he claims to be torturing him. After the mission goes awry, the two are arrested and transferred to a high-security mutant prison where they are subsequently attacked by Cable (Josh Brolin), a cybernetic mutant who wants the kid dead for future crimes. Considering the teen as his new raison d'être, Wade resumes his life as Deadpool and recruits a group of gifted individuals to help him with his mission against the time-traveler, collectively branding themselves as the X-Force.