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1916 London. Botanist Dr. Lily Houghton (Emily Blunt) tries in vain to get her research about a miraculous flower petal with revolutionary healing properties in the Amazon recognized by the scientific community through her brother MacGregor (Jack Whitehall). When every other attempt fails, she devices a plan to steal an arrowhead artifact from the museum which is rumored to be the key to locating the mysterious tree. Despite the challenges, she is successful in retrieving the remnant and soon finds her way to Brazil along with her brother to find someone to ferry them through the Amazon. Lucky for them, experienced skipper Frank Wolff (Dwayne Johnson) proves to be eager to get the job done, after seeing the relic tied around her neck. Unbeknownst to them, persistent German royal Prince Joachim (Jesse Plemons) is also after the petal and the tree to swing the tide of war into is country’s favor. Their journey into the Amazon will awaken centuries-old ghosts from the past who have also tried and failed to secure the magical petal.