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Scientist and Nobel laureate Michael Morbius (Jared Leto) has been searching for a cure for his and best friend Milo’s rare blood disease for many years, and he is finally getting closer to a breakthrough by virtue of gene splicing between human and bat DNA. Treating himself as his own guinea pig, he undergoes the human trial himself with the help of girlfriend and fellow doctor Martine Bancroft (Adria Arjona). The illegal procedure he undergoes on a cargo ship in international water east of New York works and he is temporarily cured but must face the side effect of bloodlust to maintain its effectiveness. Not wanting Milo to suffer the same fate of being a blood thirsty monster, he attempts to withhold the serum from him, but he finds a way to inject it to himself anyway. With no moral compass and a newly found freedom, Milo goes on a senseless killing spree that only Morbius himself can stop.