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September 16, 1977. Maria Callas (Angelina Jolie) dies of a heart attack at 53 in her Paris apartment. Flashback a few weeks earlier, Maria intentionally annoys her loyal butler Ferruccio (Pierfrancesco Favino) by asking him to move the piano to a different room every day while she sings to her housemaid Bruna (Alba Rohrwacher) who always tells her that she is magnificent after each impromptu performance. The truth of the matter is that the opera legend has lost her singing voice, which sets her plans in motion to recover it not so she could go back to performing for an audience but rather so she could perform for herself. Her consumption of prescription drug Mandrax results in hallucinations conjuring a young filmmaker also named Mandrax (Kodi Smit-McPhee) who is supposedly filming a documentary about her life. As she struggles with the memories of her glory days, she comes to terms with her life as La Divina accompanied by bittersweet experiences such as her relationship with a Greek magnate who dumped her for Jackie Kennedy.